Voltammetric Determination of Diazepam on Antimony Film Screen- Printed Electrode in Pharmaceutical Formulations

Background: Diazepam belongs to the group of 1,4-benzodiapines. It is used for treatment anxiety, convulsions and as muscle relaxants. The presence a 4,5-azomethine enables its electrochemical detection. Introduction: A screen-printed electrode modified with antimony film was determination diazepam in pharmaceutical preparations Methods: Electrode modification done by ex-situ deposition on commercially available electrode. Parameters affecting electroanalytical response sensor, such potential, time, concentration, were examined optimized. showed enhanced electroactivity reduction compared unmodified Under optimal conditions, linear sweep voltammetry analyte. Results: sensor dependence range from 0.5 10 μmol/L, correlation coefficient 0.9992. limit detection 0.33 corresponding quantification 1.08 μmol/L. Modification enabled oxygen. Conclusion: tablets. Results confirmed applicability sensor.