Voltammetric Amitriptyline Determination Using a Metal-Free Electrode Based on Phosphorus-Doped Multi-Walled Carbon Nanotubes

A new electrode material of phosphorus-doped multi-walled carbon nanotubes (P-MWCNTs) was developed as an electrochemical sensing element for amitriptyline (AMT). P-MWCNTs were hydrothermally synthesized and drop casted on a glassy (P-MWCNTs/GCE). The morphologically, chemically structurally characterized. characteristics the P-MWCNTs/GCE investigated by cyclic voltammetry (CV), impedance spectroscopy (EIS), adsorptive stripping (AdSV). increased electron transfer at GCE conductivity electrode. Electrocatalytic activity toward oxidation AMT excellent. In optimal voltammetric condition, produced linear ranges 0.50 to 10 ? g ml ?1 40 . limit detection (LOD) quantification (LOQ) 0.15 0.52 , respectively. sensor displayed good repeatability, reproducibility specificity. successfully quantified in pharmaceutical tablets, giving results consistent with spectrophotometric analysis. achieved recoveries from 98 ± 2% 101 5% spiked urine samples. proposed could be applied determine samples forensic toxicology.