Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis
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چکیده
منابع مشابه
Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis.
Whole-cell patch clamp recording was used to characterize calcium currents in Purkinje cells dissociated from the cerebellar vermis of 1-3-week postnatal rats. A subset of Purkinje cells had a low-threshold, transient current similar to the T-type current in peripheral neurons. All Purkinje cells had a high-threshold, slowly inactivating current. Only a small component of the high-threshold cur...
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Sodium currents were studied in granule cells dissociated from rat cerebellum. Macroscopic currents were recorded using the patch-clamp technique. Sodium currents, which are TTX sensitive, reached a maximum peak value of 0.42 +/- 0.08 pA/microns2 at 18.4 +/- 2.2 mV (n = 6). Activation and inactivation kinetics and steady-state properties were described in terms of Hodgkin and Huxley parameters....
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Cerebellar Purkinje cells are known to receive strong excitatory input from two major pathways originating outside the cerebellum and inhibitory input from two types of neurons in the cerebellar cortex. The functions and synaptic strengths of these pathways are only partially known. We have used the patch-clamp technique applied to Purkinje cells in thin slices of rat cerebellum to measure dire...
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Voltage-dependent Ca2+ conductances were investigated in Purkinje cells in rat cerebellar slice cultures using the whole-cell and cell-attached configurations of the patch-clamp technique. In the presence of 0.5 mM Ca2+ in the extracellular solution, the inward current activated with a threshold of -55 +/- 1.5 mV and reached a maximal amplitude of 2.3 +/- 0.4 nA at -31 +/- 2 mV. Decay kinetics ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1991
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.11-07-02259.1991