Voltage dependent binding of annexin V, annexin VI and annexin VII-core to acidic phospholipid membranes
نویسندگان
چکیده
منابع مشابه
Annexin V, a calcium-dependent phospholipid-binding protein.
828 Introduction Calcium regulates cellular processes by interacting with calcium-binding proteins. Two major families of calcium-binding proteins have been identified: The E-F hand proteins, which include calmodulin, SlOO and calcyclin; and the annexins (see [ l ] for review, and [2] for annexin nomenclature). Both families constitute major pools of calcium-binding activity. They are found in ...
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Annexins are a family of homologous proteins that associate with anionic phospholipid (aPL) in the presence of Ca(2+). Evidence that the function of one annexin type may be regulated by another was recently reported in studies investigating cytomegalovirus-aPL interactions, where the fusogenic function of annexin 2 (A2) was attenuated by annexin 5 (A5). This observation suggested that A2 may bi...
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Annexins constitute an evolutionary conserved multigene protein superfamily characterized by their ability to interact with biological membranes in a calcium dependent manner. They are expressed by all living organisms with the exception of certain unicellular organisms. The vertebrate annexin core is composed of four (eight in annexin A6) homologous domains of around 70 amino acids, with the ...
متن کاملBinding of recombinant annexin V to endothelial cells: effect of annexin V binding on endothelial-cell-mediated thrombin formation.
Annexin V binds with high affinity to procoagulant phospholipid vesicles and thereby inhibits the procoagulant reactions catalysed by these surfaces in vitro. In vivo, vascular endothelial cells are known to catalyse the formation of thrombin by the expression of binding sites at which procoagulant complexes can assemble. Here, we have studied the binding capacity of recombinant annexin V (rANV...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 1997
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(97)00150-8