Vitamin K Epoxide Reductase: A Protein Involved in Angiogenesis
نویسندگان
چکیده
منابع مشابه
Stereospecificity of vitamin K-epoxide reductase.
Vitamin K epoxide can occur as a pair of optical isomers due to the asymmetry of the oxirane ring substituents. The stereoselectivity of vitamin K-epoxide reductase for the oxirane ring configuration was determined by recovery of the partially resolved unreacted substrate following incubations of racemic vitamin K epoxide with rat liver microsomes. The substrate ws enriched for the (--)-enantio...
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Long-term use of warfarin has been shown to be associated with a reduced risk of prostate cancer. Warfarin belongs to the vitamin K antagonist class of anticoagulants, which inhibit vitamin K epoxide reductase (VKOR). The vitamin K cycle is primarily known for its role in γ-carboxylation, a rare post-translational modification important in blood coagulation. Here we show that warfarin inhibits ...
متن کاملVitamin K Epoxide Reductase Complex and Vascular Calcification
Vitamin K is a cofactor in the -glutamyl carboxylation pathway, a posttranslational conversion of specific glutamate residues into -carboxyglutamic acid (Gla) residues, catalyzed by the endoplasmic reticulum enzyme -glutamyl carboxylase. The substrates of carboxylase are the so-called vitamin K–dependent proteins, which are involved in diverse physiological processes such as blood coagulation, ...
متن کاملVitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum
The transfer of oxidizing equivalents from the endoplasmic reticulum (ER) oxidoreductin (Ero1) oxidase to protein disulfide isomerase is an important pathway leading to disulfide formation in nascent proteins within the ER. However, Ero1-deficient mouse cells still support oxidative protein folding, which led to the discovery that peroxiredoxin IV (PRDX4) catalyzes a parallel oxidation pathway....
متن کاملMicrosomal lipoamide reductase provides vitamin K epoxide reductase with reducing equivalents.
This study was undertaken to search for the endogenous dithiol cofactor of the reductases of the vitamin K cycle. As a starting point, the redox-active lipophilic endogenous compounds lipoic acid and lipoamide were looked at. The study shows that microsomes contain NADH-dependent lipoamide reductase activity. Reduced lipoamide stimulates microsomal vitamin K epoxide reduction with kinetics comp...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2005
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-04-0221