منابع مشابه
Vitamin K Activity and Structure
This paper presents the results of assays for antihemorrhagic activity carried out on an array of naphthoquinones and related compounds synthesized as described in a series of previous papers. Some of the compounds were prepared as synthetic models of the structural types postulat.ed (1) for vitamins K1 and Kz (l-5); others were synthesized subsequent to the establishment of the structure of vi...
متن کاملA cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites.
Warfarin and other 4-hydroxycoumarins inhibit vitamin K epoxide reductase (VKOR) by depleting reduced vitamin K that is required for posttranslational modification of vitamin K-dependent clotting factors. In vitro prediction of the in vivo potency of vitamin K antagonists is complicated by the complex multicomponent nature of the vitamin K cycle. Here we describe a sensitive assay that enables ...
متن کاملRegular Article THROMBOSIS AND HEMOSTASIS A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites
• Factor IX glutamyl carboxylation in engineered HEK 293 cells recapitulates in vivo anticoagulant inhibition of vitamin K cycle activity. • Warfarin metabolite structureactivity analysis on vitamin K cycle antagonism determines their contributions to in vivo anticoagulation. Warfarin and other 4-hydroxycoumarins inhibit vitamin K epoxide reductase (VKOR) by depleting reduced vitamin K that is ...
متن کاملPlant K+ channels: structure, activity and function.
Introduction In plants as in animals, K+ channel activity is the major determinant of cell membrane conductance [1,2]. Kt channels are therefore involved in central physiological processes such as setting the resting cell membrane potential, transducing signals and shaping action-potential waveforms. In addition, in plant cells, K t channel activity is thought to be involved in long-term fluxes...
متن کاملVitamin K–Dependent Protein Activity and Incident Ischemic Cardiovascular Disease
Vitamin K–dependent proteins (VKDPs) are a large class of proteins unified by their reliance on post-translational modification to achieve biological activity. To date, 19 VKDPs have been described, with important roles in coagulation, platelet function, and vascular biology. Prothrombin, the most welldescribed VKDP, is produced within the liver and circulates systemically until stimulation by ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1941
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)56172-5