Vitamin D, Vitamin D Binding Protein, and Longitudinal Outcomes in COPD

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Vitamin D, Vitamin D Binding Protein, and Longitudinal Outcomes in COPD

BACKGROUND Associations between Vitamin D3 [25(OH)D], vitamin D binding protein (VDBP) and chronic obstructive pulmonary disease (COPD) are previously reported. We aimed to further investigate these associations on longitudinal outcomes. METHODS 426 COPD patients from western Norway, GOLD stage II-IV, aged 40-76, were followed every six-month from 2006 through 2009 with spirometry, bioelectri...

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Vitamin D Binding Protein and Vitamin D Levels

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Vitamin D-binding protein prevents vitamin D deficiency and presents vitamin D for its renal activation.

Two mouse models in which the vitamin D-binding protein (DBP) or megalin, a DBP receptor, were knocked out have recently confirmed that DBP is essential for normal vitamin D homeostasis, and have revealed a major pathway for vitamin D activation (1, 2). DBP is also known as the group-specific component of serum (Gc-globulin). It is a highly polymorphic 58 kDa glycoprotein, which has been used a...

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Statins, vitamin D, and COPD.

2010;137;742-743 Chest Luca Mascitelli, Francesca Pezzetta and Mark R. Goldstein Statins, Vitamin D, and COPD http://chestjournal.chestpubs.org/content/137/3/742.full.html services can be found online on the World Wide Web at: The online version of this article, along with updated information and ISSN:0012-3692 ) http://chestjournal.chestpubs.org/site/misc/reprints.xhtml ( written permission of...

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The variation in free 25-hydroxy vitamin D and vitamin D-binding protein with season and vitamin D status

PURPOSE Serum 25-hydroxy vitamin D [25(OH)D] varies greatly with season at northern latitudes. The purpose of this study was to determine if the seasonal variations in serum total 25(OH)D are followed by a concomitant variation in free 25(OH)D or if the variation is damped by alterations in the binding capacity of DBP. METHODS Serum was collected from 540 healthy blood donors (60% men; mean a...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2015

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0121622