Vitamin D Binding Protein and Vitamin D Levels
نویسندگان
چکیده
منابع مشابه
Vitamin D Binding Protein and Vitamin D Levels
1 Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 2 Clinical Research, Diabetes and Endocrinology, Merck Research Laboratories, 126 East Lincoln Avenue, RY34B-148, Rahway, NJ 07065-0900, USA 3Department of Nutritional Science, Rutgers University, New Brunswick, NJ 08901, USA 4Division of Endocrinology, Metabolism an...
متن کاملVitamin D-binding protein prevents vitamin D deficiency and presents vitamin D for its renal activation.
Two mouse models in which the vitamin D-binding protein (DBP) or megalin, a DBP receptor, were knocked out have recently confirmed that DBP is essential for normal vitamin D homeostasis, and have revealed a major pathway for vitamin D activation (1, 2). DBP is also known as the group-specific component of serum (Gc-globulin). It is a highly polymorphic 58 kDa glycoprotein, which has been used a...
متن کاملVitamin D Binding Protein and Bone Health
Vitamin D binding protein (DBP) is the major carrier protein of 25-hydroxyvitamin D (25(OH) D) in the circulation, where it may serve roles in maintaining stable levels during times of decreased 25(OH) availability and in regulating delivery of 25(OH) D to target tissues. Several genetic polymorphisms of DBP have been described that lead to phenotypic changes in the protein that may affect affi...
متن کاملThe variation in free 25-hydroxy vitamin D and vitamin D-binding protein with season and vitamin D status
PURPOSE Serum 25-hydroxy vitamin D [25(OH)D] varies greatly with season at northern latitudes. The purpose of this study was to determine if the seasonal variations in serum total 25(OH)D are followed by a concomitant variation in free 25(OH)D or if the variation is damped by alterations in the binding capacity of DBP. METHODS Serum was collected from 540 healthy blood donors (60% men; mean a...
متن کاملTesting vitamin D levels.
Evidence • A systematic review1 on 25-hydroxyvitamin D (25[OH] D) suggests levels greater than 75 nmol/L “are not consistently associated with increased benefit”; greater than 50 nmol/L are “practically sufficient for all persons”; between 30 and 50 nmol/L “places some, but not all, persons at risk for inadequacy”; and less than 30 nmol/L puts one “at risk relative to bone health.” • No RCTs in...
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ژورنال
عنوان ژورنال: International Journal of Endocrinology
سال: 2014
ISSN: 1687-8337,1687-8345
DOI: 10.1155/2014/638263