Vitamin D and Neurological Diseases: An Endocrine View
نویسندگان
چکیده
منابع مشابه
Vitamin D and Neurological Diseases: An Endocrine View
Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the "non-calcemic" acti...
متن کامل[Vitamin D and endocrine diseases].
Vitamin D insufficiency/deficiency has been worldwide reported in all age groups in recent years. It has been considered a Public Health matter since decreased levels of vitamin D has been related to several chronic diseases, as type 2 diabetes mellitus (T2DM), obesity and hypertension. Glucose intolerance and insulin secretion has been observed during vitamin D deficiency, both in animals and ...
متن کاملEndocrine functions of vitamin D
The name “vitamin D” for the fat-soluble secosteroid cholecalciferol implies that humans need to take up this molecule via their diet since their own catabolism may not be able to produce it. In contrast, at UV-B (290e315 nm) exposure human skin is able to synthesize vitamin D on the basis of the cholesterol precursor 7dehydrocholesterol. Thus, insufficient exposure to sunlight in populations l...
متن کامل[The vitamin D endocrine system].
The vitamin D endocrine system comprises a group of 7-dehydrocholesterol-derived secosteroid molecules, including its active metabolite 1,25-dihydroxy-vitamin D (1,25(OH)(2)D), its precursors and other metabolites, its binding protein (DBP) and nuclear receptor (VDR), as well as cytochrome P450 complex enzymes participating in activation and inactivation pathways of those molecules. The biologi...
متن کاملHomocysteine, vitamin determinants and neurological diseases.
This review focuses on the putative role of hyper-homocysteinemia in the pathogenesis of different diseases affecting the nervous system, including stroke, Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis and amyotrophic lateral sclerosis. However, a firm pathogenic role of homocysteine in these diseases has never been established. Lowering plasma homocysteine levels troug...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2017
ISSN: 1422-0067
DOI: 10.3390/ijms18112482