Vitamin C Antagonizes the Cytotoxic Effects of Antineoplastic Drugs

Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs.

Vitamin C is an antioxidant vitamin that has been hypothesized to antagonize the effects of reactive oxygen species-generating antineoplastic drugs. The therapeutic efficacy of the widely used antineoplastic drugs doxorubicin, cisplatin, vincristine, methotrexate, and imatinib were compared in leukemia (K562) and lymphoma (RL) cell lines with and without pretreatment with dehydroascorbic acid, ...

Comment re: Vitamin C antagonizes the cytotoxic effects of chemotherapy.

On the basis of cell and animal experiments with dehydroascorbic acid, Heaney and colleagues state, “These results suggest that supplementary vitamin C may have adverse consequences in patients receiving cancer therapy” (1). Selectively referring to dehydroascorbic acid as vitamin C throughout the majority of this work may send a clouded message to patients and their caregivers. All known actio...

Low Concentration of Quercetin Antagonizes the Cytotoxic Effects of Anti-Neoplastic Drugs in Ovarian Cancer

OBJECTIVE The role of Quercetin in ovarian cancer treatment remains controversial, and the mechanism is unknown. The aim of this study was to investigate the therapeutic effects of Quercetin in combination with Cisplatin and other anti-neoplastic drugs in ovarian cancer cells both in vitro and in vivo, along with the molecular mechanism of action. METHODS Quercetin treatment at various concen...

The Potential Genotoxic Effects of Antineoplastic Drugs in Occupationally Exposed Nurses

Use of Cytotoxic Drugs

استفاده روز افزون از داروهای سایتوتوکسیک باعث شده است که پرستاران بیشتر در معرض خطرات این مواد باشند. از این رو خانم جونیت گیبز ضمن مطالعه و بررسی در این زمینه راه هایی را جهت به حداقل رساندن این خطرات مطرح می کند.