Viruses for Tumor Therapy

Tumor viruses.

It has been known for many years that infection of an experimental animal with one of a relatively small group of viruses somehow resulted in the appearance of gross tumors. Because of this and the known intimate relationships between the infecting virus and the functions of the cell it invades, many scientists have hypothesized that cancer in man may well be of viral etiology. Yet even today w...

Mathematical modeling of tumor therapy with oncolytic viruses:

BACKGROUND: One of the mechanisms that ensure cancer robustness is tumor heterogeneity, and its effects on tumor cells dynamics have to be taken into account when studying cancer progression. There is no unifying theoretical framework in mathematical modeling of carcinogenesis that would account for parametric heterogeneity. RESULTS: Here we formulate a modeling approach that naturally takes st...

Tumor Viruses and Differentiation

The UCLA Symposia on Molecular and Cellular Biology have consistently put forward volumes of the highest caliber. This, the fifth of seven such symposia published to date, certainly upholds that quality. There are, however, two structural shortcomings in this book. The first is that over half of the volume has previously been published in the Journal of Cell Biology during 1982 and 1983 (volume...

Glucocorticosteroids and RNA tumor viruses.

Glucocorticosteroids at physiological concentrations stimulated typeC virus production 2 to 50-fold from mouse fibroblasts induced by 5-iodo-2'deoxyuridine. They also stimulated virus production from chronically infected mouse myeloid leukemia cell line. Some potential practial applications of these findings are discussed. In 1971, D. R. Lowy, et al., reported that murine leukemia virus can be ...

Construction of human tumor viruses?