Virus-Induced NETs – Critical Component of Host Defense or Pathogenic Mediator?
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چکیده
منابع مشابه
Virus-Induced NETs – Critical Component of Host Defense or Pathogenic Mediator?
Much of the effort to understand and regulate the host antiviral response has been focused on adaptive immunity including high affinity, neutralizing antibody production, and the generation of specific ‘‘killer’’ CD8+ T cells. Current vaccine approaches target these effector pathways, and antibody titers or numbers of antigenspecific lymphocytes are often used as measures of the immune response...
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To support their replication, viruses take advantage of numerous cellular factors and processes. Recent large-scale screens have identified hundreds of such factors, yet little is known about how viruses exploit any of these. Influenza virus infection post-translationally activates P58(IPK), a cellular inhibitor of the interferon-induced, dsRNA-activated eIF2alpha kinase, PKR. Here, we report t...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2015
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1004546