منابع مشابه
HIV-1 viral protein R (Vpr) & host cellular responses.
During infection of host cells by HIV-1, active host-pathogen interactions take place. The final balance between these interactions determines the efficiency of viral infection and subsequent disease progression. HIV-infected cells respond to viral invasion with various antiviral strategies such as innate, cellular and humoral immune antiviral defense mechanisms. On the other hand, the virus ha...
متن کاملComparative Modeling of Viral Protein R ( VpR ) from Human Immunodeficiency Virus 1 ( HIV 1 )
During Human Immunodeficiency Virus infection interactions take place between host and the pathogen. This interaction mainly determines the efficiency of viral infection and the disease progression. Human Immunodeficiency Virus infected cells responds to several antiviral immune mechanisms such as innate, cellular and humoral immune antiviral defense. This virus has also gained resistance to su...
متن کاملViral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex.
Replication of human immunodeficiency virus type 1 (HIV-1) in non-dividing cells depends critically on import of the viral preintegration complex into the nucleus. Recent evidence suggests that viral protein R (Vpr) plays a key regulatory role in this process by binding to karyopherin alpha, a cellular receptor for nuclear localization signals, and increasing its affinity for the nuclear locali...
متن کاملActivation of the ATR-mediated DNA damage response by the HIV-1 viral protein R.
DNA damage is a universal inducer of cell cycle arrest at the G2 phase. Infection by the human immunodeficiency virus type 1 (HIV-1) also blocks cellular proliferation at the G2 phase. The HIV-1 accessory gene vpr encodes a conserved 96-amino acid protein (Vpr) that is necessary and sufficient for the HIV-1-induced block of cellular proliferation. In the present study, we examined a recently id...
متن کاملAnti-Cancer Effect of HIV-1 Viral Protein R on Doxorubicin Resistant Neuroblastoma
Several unique biological features of HIV-1 Vpr make it a potentially powerful agent for anti-cancer therapy. First, Vpr inhibits cell proliferation by induction of cell cycle G2 arrest. Second, it induces apoptosis through multiple mechanisms, which could be significant as it may be able to overcome apoptotic resistance exhibited by many cancerous cells, and, finally, Vpr selectively kills fas...
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ژورنال
عنوان ژورنال: Reviews in Medical Virology
سال: 1999
ISSN: 1052-9276,1099-1654
DOI: 10.1002/(sici)1099-1654(199901/03)9:1<39::aid-rmv235>3.0.co;2-3