Viral neuroimmunology/Viral neuropathogenesis I
نویسندگان
چکیده
منابع مشابه
Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome
The ongoing Zika virus epidemic in the Americas and the observed association with both fetal abnormalities (primary microcephaly) and adult autoimmune pathology (Guillain-Barré syndrome) has brought attention to this neglected pathogen. While initial case studies generated significant interest in the Zika virus outbreak, larger prospective epidemiology and basic virology studies examining the m...
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T combination of viral genetics and animal knockout technologies enables one to define precise molecular pathways and targets of specific viral virulence andyor host defense genes. The dual genetic knockout paper in this issue of PNAS (1) exemplifies this concept. Leib and coworkers provide convincing in vivo evidence supporting a previously proposed mechanistic basis by which herpes simplex vi...
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As the HIV-1 epidemic enters its fourth decade, HIV-1 associated neurological disorders (HAND) continue to be a major concern in the infected population, despite the widespread use of anti-retroviral therapy. Advancing age and increased life expectancy of the HIV-1 infected population have been shown to increase the risk of cognitive dysfunction. Over the past 10 years, there has been a signifi...
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In the central nervous system, the Japanese encephalitis virus can replicate only in neurons. The mechanism of the type of neurotropism was analyzed. The susceptibility to Japanese encephalitis virus infection in the rat brain was closely associated with neuronal immaturity. The initial specific binding of the virus to cells is one of the reasons for neurotropism of the Japanese encephalitis vi...
متن کاملEnvelope gene evolution and HIV-1 neuropathogenesis.
In the era of combined antiretroviral therapy (cART), HIV-associated neurocognitive disorders (HAND) account for 40 to 56% of all HIV+ cases. During the acute stage of HIV-1 infection (<6 months), the virus invades and replicates within the central nervous system (CNS). Compared to peripheral tissues, the local CNS cell population expresses distinct levels of chemokine receptors, which levels e...
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ژورنال
عنوان ژورنال: Journal of Neurovirology
سال: 2002
ISSN: 1355-0284,1538-2443
DOI: 10.1080/13550280290049840