Viral Clostridial Light Chain Gene-based Control of Penicillin-induced Neocortical Seizures
نویسندگان
چکیده
منابع مشابه
Spontaneous and artificial activation of neocortical seizures.
The aim of this study is to disclose the mechanisms underlying the recruitment of neocortical networks during slow-wave sleep oscillations evolving into spike-wave (SW) seizures. 1) We investigated the activation of SW seizures in a seizure-prone neocortex by means of electrical stimuli applied within the frequency range of spontaneous sleep oscillations. Stimuli were grouped in bursts of 10 Hz...
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Focal epilepsy is commonly pharmacoresistant, and resective surgery is often contraindicated by proximity to eloquent cortex. Many patients have no effective treatment options. Gene therapy allows cell-type specific inhibition of neuronal excitability, but on-demand seizure suppression has only been achieved with optogenetics, which requires invasive light delivery. Here we test a combined chem...
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Different forms of electrical paroxysms in experimental animals mimic the patterns of absence seizures associated with spike-wave complexes at approximately 3 Hz and of Lennox-Gastaut seizures with spike-wave or polyspike-wave complexes at approximately 1.5–2.5 Hz, intermingled with fast runs at 10 –20 Hz. Both these types of electrical seizures are preferentially generated during slow-wave sle...
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Background: Multiple sclerosis (MS) is a chronic disease characterized by inflammation and degeneration of the central nervous system (CNS). High levels of Neurofilament light chain (NFL) and Neurofilament heavy chain (NFH) in cerebrospinal fluid (CSF) have been associated with a wide range of neurological diseases including MS. Subjects and methods: Peripheral blood samples were collected from...
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Background: Febrile seizures are one of the most common neurological conditions of childhood. It seems that zinc deficiency is associated with increased risk of febrile seizures.Aim: To estimate the serum Zinc level in children with simple Febrile seizures and to find the correlation between serum zinc level and simple Febrile seizures.Materials and Methods: The proposed study was a hospital ba...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2007
ISSN: 1525-0016
DOI: 10.1038/sj.mt.6300069