Vicious circles in chronic generalized periodontitis pathogenesis
نویسندگان
چکیده
Relevance . The high prevalence of periodontal diseases, late presentation patients, especially at the early stages, ineffectiveness provided treatment, and complex still-not-fully-understood mechanisms pathogenesis diseases render chronic generalized periodontitis (CGP) a socio-medical problem.The study aims to consider pathogenic which characterize development CGP. Materials methods conducted systematic literature search, included publications from 2005 2022. studies were found by searching electronic databases PubMed Google Search. Results dental plaque microbiota is common cause contributing initiation inflammatory process in tissues. But its presence alone not enough for manifestation all pathological reactions. principal role regulating phases inflammation belongs cytokines other mediators, imbalance causes chronification process. Microvascular blood flow disorders, determine clinical manifestations, are an important part stages Cellular reactions that occur during CGP as response pathogen invasion protect tissues simultaneously induce their destruction, thereby increasing bacterial contamination. Conclusion formation intricately related several key vicious circles, including cytokine, vascular, leukocyte reparative, one most particularities pathogenesis.
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ژورنال
عنوان ژورنال: Parodontologiâ
سال: 2022
ISSN: ['1683-3759', '1726-7269']
DOI: https://doi.org/10.33925/1683-3759-2022-27-4-309-317