Vibrational analysis of peptides, polypeptides, and proteins.
نویسندگان
چکیده
منابع مشابه
Vibrational analysis of conformation in peptides, polypeptides, and proteins.
A vibrational force field for the polypeptide chain has been developed for normal-mode analysis of such molecules. I t can reproduce observed frequencies of known structures to within about 5 cm-l. We review the application of this technique to conformational problems in peptides (@-turns and their model compounds), polypeptides [the aII-helix and crystalline poly(g1ycine II)], and proteins (ba...
متن کاملVibrational analysis of peptides, polypeptides, and proteins. V. Normal vibrations of beta-turns.
T h e normal modes have been calculated for p-turns of types I, 11, 111, 1’, 11’, and 111’. The complete se t of frequencies is given for the first three structures; only the amide I, 11, and I l l modes are given for the latter three structures. Calculations have been done for structures with standard dihedral angles, as well as for structures whose dihedral angles differ from these by amounts...
متن کاملVibrational analysis of peptides, polypeptides, and proteins: XXX. Normal mode analyses of -turns
The normal modes have been calculated for three kinds of low energy y-turn structures resulting from recent conformational energy calculations by Nkmethy. Frequencies have been computed for a y-turn, a mirror-related 7-turn, and an inverse y-turn of CH3-CO-(L-Ala),-NH-CH3, with n = 3 and n = 5 , and for certain l4 C and l5 N derivatives of the n = 3 molecule. Correlations are evident between am...
متن کاملVibrational analysis of peptides, polypeptides and proteins. XXVII. Structure of gramicidin S from normal mode analyses of low-energy conformations.
Normal mode calculations have been carried out on three low-energy structures of gramicidin S obtained from conformational energy calculations. When the results on the amide modes are compared with observed bands in the infrared and Raman spectra of crystalline gramicidin S and its N-deuterated derivative, one of the structures is clearly disfavored. Of the other two, one is slightly favored, a...
متن کاملNatural peptides and proteins: potent tyrosinase inhibitors
Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals. It is involved in the first two steps of melanin biosynthesis and leads to pigmentation and different types of cancer such as melanoma. Also, it is responsible for browning of fruits and vegetab...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Peptide and Protein Research
سال: 2009
ISSN: 0367-8377
DOI: 10.1111/j.1399-3011.1984.tb02686.x