منابع مشابه
Neural guidance molecules regulate vascular remodeling and vessel navigation.
The development of the embryonic blood vascular and lymphatic systems requires the coordinated action of several transcription factors and growth factors that target endothelial and periendothelial cells. However, according to recent studies, the precise "wiring" of the vascular system does not occur without an ordered series of guidance decisions involving several molecules initially discovere...
متن کاملLocal guidance of emerging vessel sprouts requires soluble Flt-1.
Blood vessel networks form via sprouting of endothelial cells from parent vessels. Extrinsic cues guide sprouts after they leave the initiation site, but these cues are likely insufficient to regulate initial outward movement, and many embryonic vessel networks form in the absence of a strong extrinsic gradient. We hypothesized that nascent sprouts are guided by spatial cues produced along thei...
متن کاملRole of neural guidance signals in blood vessel navigation.
Despite the tremendous progress achieved in both vasculogenesis and angiogenesis in the last decade, little is still known about the molecular mechanisms underlying the pathfinding of blood vessels during their formation. However, emerging evidence shows that different axonal guidance cues, including members of the Slit and semaphorin families, are also involved in the blood vessel guidance, su...
متن کاملEndothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions.
OBJECTIVE Emerging evidence suggests that neuronal guidance cues, typically expressed during development, are involved in both physiological and pathological immune responses. We hypothesized that endothelial expression of such guidance cues may regulate leukocyte trafficking into the vascular wall during atherogenesis. APPROACH AND RESULTS We demonstrate that members of the netrin, semaphori...
متن کاملGuidance on Cardiac Tests
حضور ذهن داشتن در مورد تست های قلبی که دائما متنوع تر و اختصاصی تر شده و بیشتر توسعه می یابند، می تواند وقت گیر باشد. اما اگر شما این آزمون ها را درک نکنید نمی توانید به وضوح در مورد آنها با بیمارانتان صحبت کنید. توصیف ذیل ابزار آموزشی ویژه ای جهت کمک به توضیح ساده این تست ها می باشد.
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ژورنال
عنوان ژورنال: Nature
سال: 2007
ISSN: 0028-0836,1476-4687
DOI: 10.1038/445722a