منابع مشابه
Vesicular Traffic: A Rab SANDwich
The small GTPases Rab5 and Rab7 mark temporally distinct but sequentially connected stages in phagosome maturation, but the mechanism underlying the transition between these stages has been unclear. Recent studies in Caenorhabditis elegans have now uncovered a new protein complex that connects Rab5 to Rab7.
متن کاملThe regulatory RAB and ARF GTPases for vesicular trafficking.
While highly conserved in structure and in fundamental regulatory aspects for their activities, the RAS superfamily of monomeric GTP-binding proteins, or small GTPases, comprise a large family of regulatory molecules that collectively regulate diverse and critical cellular processes in eukaryotes. The RAB and ARF GTPases are members of two of the RAS-related subfamilies that function in regulat...
متن کاملUpdate on Vesicular Trafficking The Regulatory RAB and ARF GTPases for Vesicular Trafficking
While highly conserved in structure and in fundamental regulatory aspects for their activities, the RAS superfamily of monomeric GTP-binding proteins, or small GTPases, comprise a large family of regulatory molecules that collectively regulate diverse and critical cellular processes in eukaryotes. The RAB and ARF GTPases are members of two of the RAS-related subfamilies that function in regulat...
متن کاملEndosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet.
The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. Increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking and homoeostasis. Sterols can enter, and apparently also exit, endosomal compartments via both vesicular and non-vesicular m...
متن کاملRole of Intermediate Filaments in Vesicular Traffic
Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2010
ISSN: 0960-9822
DOI: 10.1016/j.cub.2010.02.030