Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels
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چکیده
منابع مشابه
Control of synaptic depression by glutamate transporters.
The role of glutamate transporters in the regulation of synaptic depression was examined in the avian nucleus magnocellularis. Repetitive stimulation of presynaptic auditory nerve fibers resulted in acute depression of EPSCs. Pharmacological blockade of glutamate transport in glial cells enhanced residual glutamate in the synaptic cleft and markedly increased the extent of depression at stimulu...
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developed that BNP1 might have alternative, or at least additional roles. First, mutations in a BNP1 homolog in C. elegans (eat-4) were noted to cause presynaptic An essential step in chemical synaptic transmission in-deficits in glutamatergic transmission (Berger et al., volves concentration of neurotransmitter into synaptic 1998). Second, immunocytochemical studies of BNP1 vesicles, allowing ...
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Exocytosis of synaptic vesicles occurs not only at synaptic active zones but also at ectopic sites. Ectopic exocytosis provides a direct and rapid mechanism for neurons to communicate with glia that does not rely on transmitter spillover from the synaptic cleft. In the cerebellar cortex the processes of Bergmann glia cells encase synapses between presynaptic climbing fiber varicosities and post...
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Vesicular glutamate transporters (VGLUTs) are essential to glutamatergic synapses and determine the glutamatergic phenotype of neurones. The three known VGLUT isoforms display nearly identical uptake characteristics, but the associated expression domains in the adult rodent brain are largely segregated. Indeed, indirect evidence obtained in young VGLUT1-deficient mice indicated that in cells th...
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Glutamate is the major excitatory transmitter in the brain. Vesicular glutamate transporters (VGLUT1-3) are responsible for uploading glutamate into synaptic vesicles. VGLUT1 and VGLUT2 are considered as specific markers of canonical glutamatergic neurons, while VGLUT3 is found in neurons previously shown to use other neurotransmitters than glutamate. Although there exists a rich literature on ...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2021
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2020.108623