منابع مشابه
Unconventional myosins acting unconventionally.
Unconventional myosins are proteins that bind actin filaments in an ATP-regulated manner. Because of their association with membranes, they have traditionally been viewed as motors that function primarily to transport membranous organelles along actin filaments. Recently, however, a wealth of roles for myosins that are not obviously related to organelle transport have been uncovered, including ...
متن کاملUnconventional Myosins in Inner-Ear Sensory Epithelia
To understand how cells differentially use the dozens of myosin isozymes present in each genome, we examined the distribution of four unconventional myosin isozymes in the inner ear, a tissue that is particularly reliant on actin-rich structures and unconventional myosin isozymes. Of the four isozymes, each from a different class, three are expressed in the hair cells of amphibia and mammals. I...
متن کاملUnconventional myosins, the basis for deafness in mouse and man.
Myosins are molecular motors that use the energy from ATP hydrolysis to generate force and move along actin filaments. Conventional myosin, or myosin-II, has the specialized ability to form bipolar filaments and is the basis for muscle contraction. Mutations in conventional myosins have been observed in man; dominant cardiomyopathies arise from mutations in P-cardiac myosin-II and other myosin-...
متن کاملThe roles of unconventional myosins in hearing and deafness.
The proper expression and function of several unconventional myosins are necessary for inner-ear function. Mutations in MYO7A and MYO15 cause deafness in humans, and mice. Whereas mutations in Myo6 cause inner-ear abnormalities in mice, as yet no human deafness has been found to the result of mutations in MYO6. In the mammalian inner ear there are at least nine different unconventional myosin i...
متن کاملUnconventional myosins, actin dynamics and endocytosis: a ménage à trois?
Ever since the discovery of class I myosins, the first nonmuscle myosins, about 30 years ago, the history of unconventional myosins has been linked to the organization and working of actin filaments. It slowly emerged from studies of class I myosins in lower eukaryotes that they are involved in mechanisms of endocytosis. Most interestingly, a flurry of recent findings assign a more active role ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.28.16431