Ventral Capsule/Ventral Striatum Deep Brain Stimulation Does Not Consistently Diminish Occipital Cross-Frequency Coupling
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Reply to: Ventral Capsule/Ventral Striatum Deep Brain Stimulation Does Not Consistently Diminish Occipital Cross-Frequency Coupling.
Bahramisharif et al. (1) reported that deep brain stimulation (DBS) delivered to the ventral capsule/ventral striatum (VC/VS) target for obsessive-compulsive disorder (OCD) decreased beta-gamma cross-frequency coupling (CFC) in electroencephalographic (EEG) recordings from the occipital cortex. They suggested that this may represent changes in bottom-up visual processing that may make disorder-...
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Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient regis...
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Deep brain stimulation (DBS) has been shown to be an effective treatment for neurologic disorders such as Parkinson’s disease (PD) (1) and psychiatric disorders such as obsessive-compulsive disorder (OCD) (2). However, the mechanisms underlying the therapeutic benefits of DBS are still unclear. A recent groundbreaking study reported that DBS of the basal ganglia in patients with PD is able to s...
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The primate brain has the remarkable ability of mapping sensory stimuli into motor behaviors that can lead to positive outcomes. We have previously shown that during the reinforcement of visual-motor behavior, activity in the caudate nucleus is correlated with the rate of learning. Moreover, phasic microstimulation in the caudate during the reinforcement period was shown to enhance associative ...
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BACKGROUND Recent research in humans and rodents has explored the use of deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VS) as a possible treatment for drug addiction. However, the optimum electrode placement and optimum DBS parameters have not been thoroughly studied. Here we varied stimulation sites and frequencies to determine whether DBS of the VS could facilitate the...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2016
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2015.10.029