Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status

Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1*0602 status.

We hypothesised that hypocretin (orexin) plays a role in the determination of ventilatory chemosensitivity. 130 patients with narcolepsy-cataplexy (mean ± SD age 20 ± 10 yrs, 69% male) and 117 controls (22 ± 6.9 yrs, 62% male) were recruited and tested for human leukocyte antigen (HLA)-DQB1*0602 status, hyperoxia hypercapnic (change in minute ventilation (δV'(E))/carbon dioxide tension (δP(CO(2...

Ventilatory Chemoresponsiveness, Narcolepsy-Cataplexy, and HLA-DQB1*0602 Status

Narcolepsy and Cataplexy

After hearing the punch line of the joke, the teenager falls to the floor, almost as if actually punched. She remains there, completely unable to move. She hears her parents reassure her friends that they need not worry about her because she will be all right in a few minutes. She is embarrassed and frustrated as the episode continues, and her friends begin to leave. They bid her goodbye, but s...

Narcolepsy and Cataplexy

Epidemiology [3] Prevalence is estimated as 25 per 100,000 in Caucasian populations. [4] Age of onset is typically around adolescence. A smaller number of cases presents at around 35 years. Less than 5% of narcolepsy with cataplexy occurs in children. One study found that it was often linked to complex movement disorders. [5] It is possible that incidence statistics would increase if diagnostic...

NARCOLEPSY IS TIGHTLY ASSOCIATED WITH THE HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS II RE- GION, WITH 95% OF NARCOLEPSY PATIENTS WITH cataplexy

869 Anti-Tribbles Homolog 2 Autoantibodies in Narcolepsy— Kawashima et al NARCOLEPSY IS TIGHTLY ASSOCIATED WITH THE HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS II REGION, WITH 95% OF NARCOLEPSY PATIENTS WITH cataplexy carrying the HLA-DQB1*0602 allele.1 In most human narcolepsy cases with cataplexy, hypocretin-1 concentration is reduced or undetectable in the cerebrospinal fluid (CSF).2,3 The lack of C...