منابع مشابه
Regulation of neoplastic angiogenesis.
The progressive growth of neoplasms and the production of metastasis depend on the development of adequate vasculature, i.e., angiogenesis. The extent of angiogenesis is determined by the balance between positive- and negative-regulating molecules that are released by tumor and host cells in the microenvironment. The growth of many neoplasms is associated with the absence of the endogenous inhi...
متن کاملVEGF receptor trafficking in angiogenesis.
The intracellular trafficking of receptors provides a way to control the overall sensitivity of a cell to receptor stimulation. These sorting pathways are also used to shape the balance of signals that are generated in response to receptor activation. The major pro-angiogenic growth factor receptor is VEGFR2 (vascular endothelial growth factor 2). VEGFR2 activates a very similar set of signalli...
متن کاملVEGF and Tumor Angiogenesis
Based on successful preclinical data, over twenty antiangiogenic agents, alone or in combination with conventional therapies, are now in clinical trial. In the year 2000, close to 1,000 manuscripts describing the basic molecular and cellular mechanisms that allow for an angiogenic response have been published. The goal of this review is to summarize the reasons that angiogenesis re s e a rch ha...
متن کاملAngiogenesis: bFGF and VEGF in breast carcinoma
Angiogenesis, or neovascularization, is a complex process leading to formation of new blood vessels from the pre-existing vascular network of the tissue. Angiogenesis plays a central role in various physiological and pathological conditions, including embryonic development, reproduction, inflammation and wound healing, infertility, heart diseases, ulcers, rheumatoid arthritis, diabetic blindnes...
متن کاملVEGF receptor signaling in tumor angiogenesis.
The growth of human tumors and development of metastases depend on the de novo formation of blood vessels. The formation of new blood vessels is tightly regulated by specific growth factors that target receptor tyrosine kinases (RTKs). Vascular endothelial growth factor (VEGF) and the Flk-1/KDR RTK have been implicated as the key endothelial cell-specific factor signaling pathway required for p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of the Russian academy of medical sciences
سال: 2012
ISSN: 2414-3545,0869-6047
DOI: 10.15690/vramn.v67i2.119