Vasomotor hyperresponsiveness in SCD

Aptamer therapy for SCD?

In this issue of Blood, Gutsaeva et al describe an aptamer with high affinity for murine P-selectin and its efficacy in preventing vaso-occlusion in a mouse sickle cell disease (SCD) model.1 Each year, more than 200 000 children are born with SCD,2 yet there is a paucity of treatment options available for sufferers.3 The disease is caused by homozygous expression of a mutation in the beta globi...

Scd Patterns Have Singular Diffraction

Among the many families of nonperiodic tilings known so far, SCD tilings are still a bit mysterious. Here, we determine the diffraction spectra of point sets derived from SCD tilings and show that they have no absolutely continuous part, that they have a uniformly discrete pure point part on the axis Re3, and that they are otherwise supported on a set of concentric cylinder surfaces around this...

Erythroid DAMPs drive inflammation in SCD.

Volitional vasomotor lability and vasomotor control.

This experiment tested the hypothesis that skin temperature variability during instructions to attempt skin temperature self-control without feedback (volitional vasomotor lability) predicts the acquisition of vasomotor control through biofeedback training. Skin temperature was recorded from the hands of 232 volunteers during a screening session. Twenty-three labile and 17 stabile subjects were...

Bronchial Hyperresponsiveness in Asthma*

Measurement ofnonspecific bronchial hyperresponsiveness remains largely a research tool in asthma, and its usefulness in the assessment and management of asthma is poorly defined. We StUdied the relationship of bronchial hyperresponsiveness to the clinical severity of asthma in 54 asthmatic subjects. In order to find out whether measurement of bronchial hyperresponsiveness could be used to pred...