Vascularized Bone Tissue Engineering: Approaches for Potential Improvement

Vascularized bone tissue engineering: approaches for potential improvement.

Significant advances have been made in bone tissue engineering (TE) in the past decade. However, classical bone TE strategies have been hampered mainly due to the lack of vascularization within the engineered bone constructs, resulting in poor implant survival and integration. In an effort toward clinical success of engineered constructs, new TE concepts have arisen to develop bone substitutes ...

Engineering Pre-vascularized Scaffolds for Bone Regeneration.

Survival of functional tissue constructs of clinically relevant size depends on the formation of an organized and uniformly distributed network of blood vessels and capillaries. The lack of such vasculature leads to spatio-temporal gradients in oxygen, nutrients and accumulation of waste products inside engineered tissue constructs resulting in negative biological events at the core of the scaf...

Engineering Vascularized Human Adipose Tissue

Introduction Due to complications of currently available therapies, the clinical impetus to engineer adipose tissue for the correction of soft tissue defects is high. Unfortunately, poor survival of in vitro-engineered adipose tissue after transplantation is still a major hurdle for clinical use. The main reason for this poor survival is postulated to be insufficient vascularization. In this st...

Human DPSCs fabricate vascularized woven bone tissue: a new tool in bone tissue engineering

Human dental pulp stem cells (hDPSCs) are mesenchymal stem cells that have been successfully used in human bone tissue engineering. To establish whether these cells can lead to a bone tissue ready to be grafted, we checked DPSCs for their osteogenic and angiogenic differentiation capabilities with the specific aim of obtaining a new tool for bone transplantation. Therefore, hDPSCs were specific...

Poly(lactic acid) (PLA) Nanofibers for Bone Tissue Engineering