Varying coefficient model for gene–environment interaction: a non-linear look

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Varying coefficient model for gene-environment interaction: a non-linear look

MOTIVATION The genetic basis of complex traits often involves the function of multiple genetic factors, their interactions and the interaction between the genetic and environmental factors. Gene-environment (G×E) interaction is considered pivotal in determining trait variations and susceptibility of many genetic disorders such as neurodegenerative diseases or mental disorders. Regression-based ...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2011

ISSN: 1460-2059,1367-4803

DOI: 10.1093/bioinformatics/btr318