Varicella-zoster virus as a live vector for the expression of foreign genes.
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چکیده
منابع مشابه
Recombinant Varicella-Zoster Virus Vaccines as Platforms for Expression of Foreign Antigens
Varicella-zoster virus (VZV) vaccines induce immunity against childhood chickenpox and against shingles in older adults. The safety, efficacy, and widespread use of VZV vaccines suggest that they may also be effective as recombinant vaccines against other infectious diseases that affect the young and the elderly. The generation of recombinant VZV vaccines and their evaluation in animal models a...
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Since vaccinia virus was first used to protect against smallpox in the eighteenth century, live attenuated vaccines have proved to be highly effective in reducing the morbidity and mortality caused by many human viral pathogens. Contemporary live viral vaccines are designed using several different strategies to achieve attenuation. These basic principles and approaches are illustrated by vaccin...
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Introduction: After COVID-19 pandemic in 2020 that mostly affects upper respiratory tract, the scientists investigated an effective vaccine against the virus. As the vaccination of general population started some patients were visited with varicella zoster virus activation following the COVID vaccine.
متن کاملVaricella zoster virus.
Because of its ability to produce two clinically distinct disease entities (chickenpox and shingles), varicella zoster virus (VZV) is an unusual etiologic agent. Although in the past viral exanthems were mostly only of academic interest to the practitioner, the development of antiviral agents and the newly approved varicella (OKA) vaccine have increased the clinical significance. Also, with the...
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A 47-year-old woman with history of systemic lupus erythematous on prednisolone presented to our emergency department with fever and back pain for 5 days along with progressive muscle weakness on left lower leg. Cerebrospinal fluid (CSF) revealed pleocytosis with mononuclear leukocyte predominance. Brain and spine Magnetic Resonance Imaging (MRI) revealed multiple high intensity areas on cerebr...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1987
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.84.11.3896