VARIATION OF EOSINOPHIL CELLS IN NASAL ALLERGY

Nasal polyposis, eosinophil dominated inflammation, and allergy.

A polyp is an oedematous mucous membrane which forms a pedunculating process with a slim or broad stalk or base. Nasal polyps originate in the upper part of the nose around the openings to the ethmoidal sinuses. The polyps extend into the nasal cavity from the middle meatus, resulting in nasal blockage and restricted airflow to the olfactory region. The polyp stroma is highly oedematous with a ...

Highlight : Eosinophil extra - cellular traps in Allergy

Eosinophil degranulation has always aroused the interests of physicians and scientists alike. Loss of viability and release of membrane-free granules upon eosinophil degranulation was first demonstrated by Gleich and coworkers in 1996. These free eosinophil granules, once considered as crush artifacts, are now confirmed products of eosinophil cytolysis, and suggested to be significantly pathoge...

Mechanisms of the Development of Nasal Hyperreactivity in Nasal Allergy

Nasal hyperreactivity in nasal allergy conditions is closely related to allergic inflammation, particularly to infiltration by activated eosinophils in the nasal mucosa, observed 4 to 10 hours after a single antigenic challenge. Repeated antigenic challenge in subjects with nasal allergy enhanced nasal hyperreactivity. On the other hand, various therapies including topical steroids, immunothera...

Nasal allergy: milestones in understanding the disease.

Tumour necrosis factor-α in nasal allergy

Tumour necrosis factor-alpha (TNF-alpha) was measured by enzyme-linked immunosorbent assay and eosinophil cationic protein (ECP) by radio-immunoassay to evaluate TNF-alpha in nasal allergy. There was no significant difference either between the mean concentrations of TNF-alpha in nasal secretions from the patients with perennial nasal allergy and those of normal subjects, or between the TNF-alp...