Variation of chemical composition with age in human femoral head cartilage.

Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition.

Radiochemical and biochemical methods were used to characterize post-mortem and osteoarthrotic femoral head cartilage. Fixed charge density measurements were correlated with glycosaminoglycan content as estimated by uronic acid and hexosamine analyses. In post-mortem cartilage water content decreased from a maximum at the surface to a minimum in the deep zones. In the osteoarthrotic specimens ...

Further studies on the composition of human femoral head cartilage.

This report continues our previous studies on the composition and swelling of articular cartilage. When the protein part of the proteoglycan moiety has been taken into consideration, there is no longer a large fraction of the tissue which is not accounted for. In fact, the collagen, proteoglycans, and free electrolyte represent over 92% of the dry weight of adult femoral head cartilage, the rem...

Thickness and distribution of human femoral head articular cartilage. Changes with age.

The distribution of hyaline cartilage in the sagittal plane of the normal human femoral head was examined. 28 specimens from persons aged 10 to 68 years subject to post-mortem examination in a teaching hospital were anatomically orientated and x-rayed in a lateromedial projection. An optical technique was used to measure the cartilage thickness from the x-ray films thus produced. Measurements w...

Cathepsin B in osteoarthritis: zonal variation of enzyme activity in human femoral head cartilage.

OBJECTIVES To determine the quantitative topographical distribution of cathepsin B in human femoral head cartilage by measuring the zonal variation of enzyme activity in specimens taken from various anatomical regions of normal and osteoarthritic (OA) tissues, and to correlate this parameter with the severity of the OA lesions. METHODS OA articular cartilage was obtained at surgery for total ...

Diurnal Variation in Distal Femoral Cartilage Thickness.