Variant haemoglobin may affect measurements

Interleukin-8 but Not Interleukin-6 Variant May Affect Susceptibility to Brucellosis

Background: Increased levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in acute human brucellosis have been reported. Previous studies have shown that the production and level of IL-6 and IL-8 cytokines are associated with the polymorphism of the encoding genes. Objective: To investigate the probable association between IL-6 (-174 C/G) and IL-8 (-251 A/T) gene polymorphisms and susceptib...

Measurements for haemoglobin.

interleukin-8 but not interleukin-6 variant may affect susceptibility to brucellosis

background: increased levels of interleukin-8 (il-8) and interleukin-6 (il-6) in acute human brucellosis have been reported. previous studies have shown that the production and level of il-6 and il-8 cytokines are associated with the polymorphism of the encoding genes. objective: to investigate the probable association between il-6 (-174 c/g) and il-8 (-251 a/t) gene polymorphisms and susceptib...

Haemoglobin hope and glycated haemoglobin: one peak may or may not hide the other, depending on the assay.

Haemoglobin A1c (HbA1c), or glycated haemoglobin, is he product of a non-enzymatic reaction of glycation and an mportant biochemical marker that is widely used to estimate ong-term glycaemic control in diabetic patients. Given the averge lifespan of red blood cells, this marker allows the evaluation f glycaemic control over the past 2–3 months as well as the uture risk of developing diabetes-re...

A variant in the SCN10A enhancer may affect human mechanical pain sensitivity

Expression of Nav1.8, encoded by SCN10A, can affect pain transmission and thus mediate the human pain phenotype. In the current study, we assessed whether the variant rs6801957, located in the SCN10A enhancer region, may have the potential to affect human pain. Through dual-luciferase reporter assays in 293T cells, we found that the SCN10A enhancer A (Enh-A) increased the activity of the SCN10A...