Variable human minisatellite-like regions in the Mycobacterium tuberculosis genome
نویسندگان
چکیده
منابع مشابه
Probing the human genome with minisatellite-like sequences from the human coagulation factor VII gene.
The huaan factor VII gene contains five ainisatallite-like elements (MLEs), one in the untranslated portion of the eighth exon and four in introns (1). Two of the HLEe, one in exon 8 and one in intron B, consist of tandem repeats related to siailar consensus sequences (ATGCACACACACAGG) and ( (T/A)CACCTCACACTCACAGG) respectively. The monomer elements of the exon 8 MLE are loosely related to its ...
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1. Minisatellites, originally developed for forensic DNA fingerprinting and profiling, have also provided extremely informative systems for analysing processes of tandem repeat DNA turnover in the human genome. 2. Minisatellite instability involves distinct mutation processes in somatic and germline cells. In sperm, tandem repeat instability most likely arises at meiosis as a by-product of high...
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Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured population genetics, some of which have been linked to ancient human migrations. However, no study has addressed the potential evolutionary consequences of such longstanding human-pathogen associations. Here, we demonstrate that the globa...
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Recent studies have implicated a family of mammalian Toll-like receptors (TLR) in the activation of macrophages by Gram-negative and Gram-positive bacterial products. We have previously shown that different TLR proteins mediate cellular activation by the distinct CD14 ligands Gram-negative bacterial LPS and mycobacterial glycolipid lipoarabinomannan (LAM). Here we show that viable Mycobacterium...
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The mutifractal and long range correlation (C(r)) properties of strings, such as nucleotide sequence can be a useful parameter for identification of underlying patterns and variations. In this study C(r) and multifractal singularity function f(α) have been used to study variations in the genomes of a pathogenic bacteria Mycobacterium tuberculosis. Genomic sequences of M. tuberculosis isolates d...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2002
ISSN: 0950-382X,1365-2958
DOI: 10.1046/j.1365-2958.2000.01905.x