Valvular interstitial cells suppress calcification of valvular endothelial cells
نویسندگان
چکیده
منابع مشابه
Calcification of Porcine Aortic Valvular Interstitial Cells
Calcific aortic stenosis (AS), stiffening of aortic valve leaflets and narrowing of the aortic orifice, is the most common heart valve disease in developed countries [1]. The aortic valve is located between the aorta and the left ventricle and consists of 3 leaflets. Each leaflet contains outer endothelial layers and interstitial cells interspersed in the matrix between the endothelial layers. ...
متن کاملIsolation of valvular endothelial cells.
Heart valves are solely responsible for maintaining unidirectional blood flow through the cardiovascular system. These thin, fibrous tissues are subjected to significant mechanical stresses as they open and close several billion times over a lifespan. The incredible endurance of these tissues is due to the resident valvular endothelial (VEC) and interstitial cells (VIC) that constantly repair a...
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Endothelial cells are critical mediators of haemodynamic forces and as such are important foci for initiation of vascular pathology. Valvular leaflets are also lined with endothelial cells, though a similar role in mechanosensing has not been demonstrated. Recent evidence has shown that valvular endothelial cells respond morphologically to shear stress, and several studies have implicated valvu...
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1) Takeda Y, Hoshiga M, Tatsugami F, Morinaga I, Takehara K, Hotchi J, Yuki T, Ishihara T, Hanafusa T: Clinical Significance of Calcification in Ascending Aorta as a Marker for the Requirement of Coronary Revascularization. J Atheroscler Thromb, 2009 Aug 27. [Epub ahead of print] 2) Eisen A, Tenenbaum A, Koren-Morag N, Tanne D, Shemesh J, Imazio M, Fisman EZ, Motro M, Schwammenthal E, Adler Y: ...
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objective: the incidence of heart valve disease is increasing worldwide and the number of heart valve replacements is expected to increase in the future. by mimicking the main tissue structures and properties of heart valve, tissue engineering offers new options for the replacements. applying an appropriate scaffold in fabricating tissue-engineered heart valves (tehvs) is of importance since it...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2015
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2015.07.008