Value of composite reference standards in diagnostic research

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Value of composite reference standards in diagnostic research.

A common challenge in diagnostic studies is to obtain a correct final diagnosis in all participants. Ideally, a single error-free reference test, known as a gold standard, is used to determine the final diagnosis and estimate the accuracy of the test or diagnostic model under evaluation. If the reference standard does not perfectly correspond to true target disease status, estimates of the accu...

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Evaluating diagnostic accuracy in the face of multiple reference standards.

A universal challenge in studies that quantify the accuracy of diagnostic tests is establishing whether each participant has the disease of interest. Ideally, the same preferred reference standard would be used for all participants; however, for practical or ethical reasons, alternative reference standards that are often less accurate are frequently used instead. The use of different reference ...

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Utility of composite reference standards and latent class analysis in evaluating the clinical accuracy of diagnostic tests for pertussis.

Numerous evaluations of the clinical sensitivity and specificity of PCR and serologic assays for Bordetella pertussis have been hampered by the low sensitivity of culture, the gold standard test, which leads to biased accuracy estimates. The bias can be reduced by using statistical approaches such as the composite reference standard (CRS) (e.g., positive if culture or serology positive; negativ...

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Local Diagnostic Reference Levels for Some Common Diagnostic X-Ray Examinations In Sabzevar County of Iran

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ژورنال

عنوان ژورنال: BMJ

سال: 2013

ISSN: 1756-1833

DOI: 10.1136/bmj.f5605