Validity of routine biochemical and ultrasound scores for prediction of hepatic fibrosis and steatosis in NAFLD

Abstract Background We evaluated the validity of some non-invasive scores and ultrasound findings to predict fibrosis steatosis in a cohort NAFLD patients who underwent liver biopsy. Ninety-seven were enrolled classified into NASH (66) simple groups (31) based on ROC curves constructed for Fibrosis-4 index (FIB4), aspartate aminotransferase platelet ratio ( APRI), score (NFS) prediction, also (hepatic index; HSI, fatty FLI) ultrasonographic subcutaneous visceral adipose tissue measurements (SAT VAT) prediction. Results FIB4 had AUC 0.6, APRI NFS at cutoffs 0.3 -.2.4 0.64 0.63 detecting presence any grade fibrosis, (0.52, 0.55, 0.58) significant fibrosis. cut-off (0.76) highest group (0.81). SAT (at cutoff 2.1 2.5) was superior VAT. HSI 45.35 45.7) FLI moderate or marked steatosis. Conclusion can be used screening silent disease with ongoing They are unsatisfactory predictors NAFLD. is better than VAT predicting slightly biochemical HSI.