Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach
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چکیده
منابع مشابه
Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity.
A microfluidic-based biochip made of poly-(dimethylsiloxane) was recently reported for the first time by us for the incubation of precision-cut liver slices (PCLS). In this system, PCLS are continuously exposed to flow, to keep the incubation environment stable over time. Slice behavior in the biochip was compared with that of slices incubated in well plates, and verified for 24 h. The goal of ...
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Hepatic stellate cell (HSC) activation is a key event in the natural process of wound healing as well as in fibrosis development in liver. Current in vitro models for HSC activation contribute significantly to the understanding of HSC biology and fibrogenesis but still fall far short of recapitulating in vivo intercellular functional and anatomic relationships. In addition, when cultured on unc...
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ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2016
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-016-1778-8