Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images
نویسندگان
چکیده
منابع مشابه
Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images.
UNLABELLED (123)I-FP-CIT ((123)I-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)nortropane) is a SPECT dopamine transporter (DAT) tracer that probes dopaminergic cell loss in Parkinson's disease (PD). Quantification of (123)I-FP-CIT images is performed at equilibrium using a ratio (BR) of specific (striatal) to nonspecific (occipital) uptake with values obtained from regions of int...
متن کاملValidation of Optimum ROI Size for 123I-FP-CIT SPECT Imaging Using a 3D Mathematical Cylinder Phantom
Objective(s): The partial volume effect (PVE) of single-photon emission computed tomography (SPECT) on corpus striatum imaging is caused by the underestimation of specific binding ratio (SBR). A large ROI (region of interest) set using the Southampton method is independent of PVE for SBR. The present study aimed to determine the optimal ROI size with contrast and SBR for striatum images and val...
متن کاملStandardized Semi-Quantitative Evaluation of [123I]FP-CIT SPECT in a Multicenter Study
Background and Purpose: To the best of our knowledge no multicenter studies have been published using standardized semi-quantitative evaluation of [123I]FP-CIT scan (DAT-SPECT). The aims of this study were: 1) to cross-compare semi-quantitative software-assisted evaluations of DAT-SPECTs performed in three centers with different equipments; 2) to assess the accuracy of semi-quantitative evaluat...
متن کاملReproducibility of a standardized quantitative analysis using fixed regions of interest to differentiate movement disorders on 123I-FP-CIT SPECT.
UNLABELLED The present prospective study evaluated the diagnostic value of a standardized analysis of (123)I-N-omega-(fluoropropyl)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane (FP-CIT) SPECT studies acquired on a triple-head gamma-camera for patients with clinically uncertain movement disorders having tremor as the most striking feature. METHODS (123)I-FP-CIT studies were performed on 52 c...
متن کاملAutopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB
OBJECTIVE To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS Patients >60 years of age with dementia who had undergone 123I-FP-CIT imaging in research studies and who had donated their brain tissue to th...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2007
ISSN: 0161-5505
DOI: 10.2967/jnumed.106.038646