Validation and Reproducibility Assessment of Tigecycline MIC Determinations by Etest
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چکیده
منابع مشابه
Validation and reproducibility assessment of tigecycline MIC determinations by Etest.
A multicenter study was conducted to validate Etest tigecycline compared to the Clinical Laboratory Standards Institute reference broth microdilution and agar dilution methodologies. A large collection of gram-negative (n = 266) and gram-positive (n = 162) aerobic bacteria, a collection of anaerobes (n = 385), and selected collections of nonpneumococcal streptococci (n = 369), Streptococcus pne...
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Tigecycline is often one of the few therapeutic options for infections by multidrug-resistant Gram-negative bacteria. Therefore, accurate MIC testing is critical. Since in many laboratories tigecycline is not included in the routine panel of antibiotics for susceptibility testing, tigecycline MICs are frequently determined by Etest. However, previous studies have shown that tigecycline MICs det...
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MICs of tigecycline determined by Etest were 4 to 12 times (three ATCC strains) and 2 to 8 times (50 clinical isolates) higher in Mueller-Hinton agar from Merck than in Mueller-Hinton agar from either Oxoid or Difco. This was related to a much higher concentration of manganese in the medium from Merck.
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2007
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.00089-07