Vagus nerve stimulation for medically refractory absence epilepsy

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Vagus nerve stimulation for medically refractory absence epilepsy

PURPOSE A proportion of patients with childhood and juvenile absence epilepsies (CAE, JAE) are likely to be classified as medically refractory. In view of evidence gap for the treatment of such patients, this series is reported to generate estimate for efficacy of vagus nerve stimulation (VNS) in this patient population. METHODS Patients were identified by a chart review of all VNS recipients...

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Vagus nerve stimulation for refractory epilepsy

Vagus nerve stimulation (VNS) is a neurophysiological treatment for patients with medically or surgically refractory epilepsy. Since the first human implant in 1989, more than 10 000 patients have been treated with VNS. Two randomized controlled studies have shown a statistically significant decrease in seizure frequency during a 12-week treatment period versus a baseline period when 'high stim...

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Vagus Nerve Stimulation for Refractory Epilepsy

Context: Vagus nerve stimulation (VNS) is a relatively new treatment for epilepsy. Past studies have proposed that the antiepileptic action is related to the effect on the brainstem reticular activating system, and is mediated largely by the widespread release of two inhibitory agents (gamma aminobutyric acid [GABA] and glycine). Objective: To confirm the safety and efficacy of vagus nerve stim...

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Cost-utility of vagus nerve stimulation (VNS) therapy for medically refractory epilepsy—An update

Cost-utility of vagus nerve stimulation (VNS) therapy for medically refractory epilepsy–—An update Dear Sir, In a previous health technology assessment, the cost-utility of VNS therapy was calculated as £28,849 per quality-adjusted life year (QALY) gained. 1 This economic model assumed that the device's life expectancy was at best 5 years, and that the number needed to treat was 6 to produce on...

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Vagus Nerve Stimulation for Medically Refractory Epilepsy in Children with Brain Malformations

Vagal nerve stimulation is approved for medically refractory partial epilepsy in children older than 12 years of age. However, it has been shown in the literature that vagal nerve stimulation is also quite efficacious in children younger than 12 with generalized epilepsy and brain malformations. We report a case series of children younger than 12 who responded well to vagal nerve stimulation. A...

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ژورنال

عنوان ژورنال: Seizure

سال: 2013

ISSN: 1059-1311

DOI: 10.1016/j.seizure.2013.01.008