Vaccine Delivery to the Oral Cavity Using Coated Microneedles Induces Systemic and Mucosal Immunity
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چکیده
منابع مشابه
Coated microneedles for transdermal delivery.
Coated microneedles have been shown to deliver proteins and DNA into the skin in a minimally invasive manner. However, detailed studies examining coating methods and their breadth of applicability are lacking. This study's goal was to develop a simple, versatile and controlled microneedle coating process to make uniform coatings on microneedles and establish the breadth of molecules and particl...
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Easy and effective vaccination methods could reduce mortality rates and morbidity due to vaccine-preventable influenza infections. In this study, we examined the use of microneedle patches to increase patient coverage through possible self-administration and enhance vaccine immunogenicity by targeted delivery to skin. We carried out a detailed study of protective immune responses after a single...
متن کاملCoated microneedles for drug delivery to the eye.
PURPOSE To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner. METHODS Solid metal microneedles measuring 500 to 750 microm in length were coated with model drugs, protein, and DNA; inserted into nonpreserved human cadaveric sclera; and imaged. Microneedles coated with sodium fluorescein were then...
متن کاملMicroneedles-mediated drug and vaccine delivery
Several decades past, the concept of microneedles was laid down but turned out to be the area under research in the mid 1990’s due to their production via microfabrication technology. A plethora of troubles has been associated with injection by needle-and-syringe-based delivery of drug and vaccine comprising patient compliance and acceptability, pain of needles, needlestick injuries, requiremen...
متن کاملMicroneedles for drug and vaccine delivery.
Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990's when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encaps...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2014
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-014-1335-1