V-cGAPs: attenuators of 3′3′-cGAMP signaling
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چکیده
منابع مشابه
cGAMP: A tale of two signals
DNA, when inadvertently present in the cytosol, acts as a danger signal alarming the host of infection or cellular damage and triggers a potent innate immune response characterized by the induction of type I IFNs and proinflammatory cytokines. The two major DNA sensors mediating these responses are the cyclic GMP-AMP synthase (cGAS) and the inflammasome forming receptor absent in melanoma 2 (AI...
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Immunotherapy is one of the key strategies for cancer treatment. The cGAS-cGAMP-STING-IRF3 pathway of cytosolic DNA sensing plays a pivotal role in antiviral defense. We report that the STING activator cGAMP possesses significant antitumor activity in mice by triggering the STING-dependent pathway directly. cGAMP enhances innate immune responses by inducing production of cytokines such as inter...
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متن کاملcGAMP: A tale of two signals
DNA, when inadvertently present in the cytosol, acts as a danger signal alarming the host of infection or cellular damage and triggers a potent innate immune response characterized by the induction of type I IFNs and proinflammatory cytokines. The two major DNA sensors mediating these responses are the cyclic GMP-AMP synthase (cGAS) and the inflammasome forming receptor absent in melanoma 2 (AI...
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This research is aimed at problems of interest in communication systems. Principles of transistor circuit design and practical limitations imposed by available devices are being investigated for circuits useful in a wide variety of applications. At the present time problems pertaining to gain control in transistor amplifiers are being investigated. The study of noise in semiconductors is a clos...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2015
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2015.48