Utility of minor determinants in penicillin allergy skin testing
نویسندگان
چکیده
منابع مشابه
Utility of minor determinants in penicillin allergy skin testing
Background Penicillin allergy is a major concern among patients and physicians. There’s an estimated 5-10% self reported history of penicillin allergy by patients, but vast majority are not true hypersensitivities. Complete penicillin skin test with both major, minor determinants and amoxicillin is the test of choice for diagnosing IgE-mediated penicillin allergy. While Penicilloyl polylysine (...
متن کاملPenicillin allergy: anti-penicillin IgE antibodies and immediate hypersensitivity skin reactions employing major and minor determinants of penicillin.
300 children considered to have had adverse reactions to penicillin were examined. Informed consent was obtained from the parents. Skin tests were conducted by the scratch/prick and intradermal techniques, using benzylpenicilloyl polylysine conjugate and a mixture of minor determinants of penicillin. Specific anti-penicillin IgE antibodies were estimated by the radioallergosorbent test. There w...
متن کاملUtility of penicillin allergy testing in patients presenting with a history of penicillin allergy
BACKGROUND Current statistics show that approximately 10% of patients claim to be allergic to penicillin yet only 10% of these have demonstrable allergy. The most appropriate and cost-effective antibiotics are sometimes withheld on the basis of patient history of drug allergy. OBJECTIVE Investigation of IgE hypersensitivity and delayed hypersensitivity in patients with a history of penicillin...
متن کاملRoutine Penicillin Skin Testing in Hospitalized Patients with a History of Penicillin Allergy.
BACKGROUND In selected inpatient settings, penicillin skin testing has been shown to affect antibiotic use. Routine penicillin skin testing has not been studied in hospitalized patients with a history of penicillin allergy. OBJECTIVES To determine whether routine penicillin skin testing at a large regional hospital affected antibiotic use and/or antibiotic side effects in hospitalized persons...
متن کاملSkin testing only with penicillin G in children with a history of penicillin allergy.
BACKGROUND The absence of commercially available penicilloyl-polylysine (PPL) for most of the last decade severely hampered the practice of penicillin allergy evaluation because skin testing without PPL is reported to have a poor negative predictive value (NPV). OBJECTIVE To determine the safety and NPV of skin testing without PPL using only penicillin G followed by a 3-dose graded challenge ...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2015
ISSN: 1939-4551
DOI: 10.1186/1939-4551-8-s1-a228