Uterine NK cell development, migration and function
نویسندگان
چکیده
منابع مشابه
The regulation of NK cell function and development.
NK cells are the lymphocytes that are differentiated from hematopoietic stem cells in bone marrow (BM) through sequential acquisition of functional receptors. They are one of the critical components of innate immune system. The process of NK differentiation involves a variety of factors such as cytokines, membrane factors, and transcription factors in addition to BM microenvironment. NK cells e...
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Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines. Interleukin (IL)-15 is pivotal for their development, homeostasis, and activation. Moreover, numerous other activating or inhibitory cytokines such as IL-2, IL-4...
متن کاملUterine NK cells and macrophages in pregnancy.
The presence of immune cells in the placental bed is important for both mother and child. Although various immune cells can be found in the placental bed, such as regulatory T cells and dendritic cells, uterine NK cells and macrophages are the most prominent immune cells in the placental bed in early pregnancy. uNK cell and macrophage numbers in the placental bed decrease in the third trimester...
متن کاملImpaired NK cell function in ESRD patients.
(humoral immune response). Alternatively, if IL-12 and IL-18 are predominant, a Th1 response is initiated leading to the secretion of IL-2 and interferon (IFN) and the stimulation of cytotoxic T cells and NK cells (cellular immune response). Several studies in patients with ESRD demonstrated the preactivation of circulating monocytes [2, 3] . The Th1 response may be disturbed on the level of a...
متن کاملAssessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy.
In mouse and human, precursors of NK cell lineage home to decidualizing uteri. To assess the requirement for IL-15, an essential cytokine for NK differentiation in lymphoid tissue, on uterine NK (uNK) cell differentiation, implantation sites from IL-15(-/-) mice were analyzed histologically. IL-15(-/-) implantation sites had no uNK cells, no spiral-artery modification, and lacked the decidual i...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2008
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(10)60575-5