Using three-color chromosome painting to test chromosome aberration models.
نویسندگان
چکیده
منابع مشابه
Prompt cytomolecular identification of chromosome aberration in irradiated blood cells
Background: understanding the genomic alteration induced by ionizing radiation still remains to be a methodological challenge in genetic field. The energy released from this type of radiation can potentially causes structural and numerical alterations in lymphocytes, which in turn converts them into abnormal tumor cells. Chromosomal abnormalities associated with specific type of hematological m...
متن کاملChromosome Painting in Marsupials.
To generate a model of mammalian karyotype evolution and to extend our knowledge of the evolutionary relationships of mammals, it is helpful to deduce ancestral chromosomal arrangements. Of particular interest would be a global comparison among the 3 major extant groups of mammals, since this would reveal the most ancient arrangements of the mammalian genome and allow us to follow chromosomal r...
متن کاملB. 10. Mutagenicity – in Vitro Mammalian Chromosome Aberration Test
The purpose of the in vitro chromosomal aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian cells (1)(2)(3). Structural aberrations may be of two types, chromosome or chromatid. With the majority of chemical mutagens, induced aberrations are of the chromatid type, but chromosome-type aberrations also occur. An increase in polyploidy may indic...
متن کاملIn vivo chromosome aberration test for hydroxyapetite in mice.
This study evaluates the cytotoxic and mutagenic effect of synthetic hydroxyapatite granules (source: School of Material and Mineral Resources Engineering, Universiti Sains Malaysia) in the bone marrow cells of mice. Mice are exposed to synthetic hydroxyapatite granules, the bone marrow cells are collected and observed for chromosome aberrations. No chromosome aberrations were noticed in the an...
متن کاملMutagenicity – in Vivo Mammalian Bone Marrow Chromosome Aberration Test
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by the test substance to the bone marrow cells of animals, usually rodents (1)(2)(3)(4). Structural chromosome aberrations may be of two types, chromosome or chromatid. An increase in polyploidy may indicate that a chemical has the potential to induce numerical aberrations. Wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1993
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.90.4.1484