Using Microscopy to Qualitatively and Quantitatively Assess Crystalline Content in Amorphous Active Pharmaceutical Ingredients and Drug Product

Estimation of active pharmaceutical ingredients content using locally weighted partial least squares and statistical wavelength selection.

Development of quality estimation models using near infrared spectroscopy (NIRS) and multivariate analysis has been accelerated as a process analytical technology (PAT) tool in the pharmaceutical industry. Although linear regression methods such as partial least squares (PLS) are widely used, they cannot always achieve high estimation accuracy because physical and chemical properties of a measu...

Recrystallization of Active Pharmaceutical Ingredients

Composite Hydrogels Laden with Crystalline Active Pharmaceutical Ingredients of Controlled Size and Loading

Efficient control of crystallization and crystal properties still represents a bottleneck in the manufacturing of crystalline materials ranging from pigments to semiconductor particles. In the case of pharmaceutical drug manufacture, current methods for controlling critical crystal properties such as size and morphology that dictates the product’s efficacy are inefficient and often lead to the ...

How to Qualitatively + Quantitatively Assess Concepts Maps: the case of COMPASS

This paper presents a scheme for the quantitative and qualitative assessment of concept maps in the context of a web-based adaptive concept map assessment tool, referred to as COMPASS. The propositions are characterized qualitatively based on specific criteria and on the error(s) that may be identified. The quantitative assessment depends on the weights assigned to the concepts/propositions and...

on the equivalence of constructed-response and multiple-choice : stem-equivalent, stem non-equivalent but content equivalent, and stem and content non-equivalent items in reading comprehension using multifaceted rasch

the present study investigated construct equivalence of multiple choice (mc) and constructed response (cr) item types across stem and content equivalent mc and cr items (item type ‘a’), non-stem-equivalent but content equivalent mc and cr items (item type ‘b’), and non-stem and non-content equivalent mc and cr items (item type ‘c’). one hundred seventy english-major undergraduates completed mc ...