Using a Simple Cellular Assay to Map NES Motifs in Cancer-Related Proteins, Gain Insight into CRM1-Mediated NES Export, and Search for NES-Harboring Micropeptides
نویسندگان
چکیده
منابع مشابه
NESdb: a database of NES-containing CRM1 cargoes
The leucine-rich nuclear export signal (NES) is the only known class of targeting signal that directs macromolecules out of the cell nucleus. NESs are short stretches of 8-15 amino acids with regularly spaced hydrophobic residues that bind the export karyopherin CRM1. NES-containing proteins are involved in numerous cellular and disease processes. We compiled a database named NESdb that contain...
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Sneaking late night snacks might just seem like an unhealthy habit, but the truth is that night eating syndrome (NES) ? and a related syndrome called sleep related eating disorder (SRED) ? are actually diagnosable conditions for some people. NES is technically classified as disordered eating [2], but researchers believe it?s also related to sleep disorders, making it a sort of hybrid condition....
متن کاملNight eating syndrome (NES)
Sneaking late night snacks might just seem like an unhealthy habit, but the truth is that night eating syndrome (NES) ? and a related syndrome called sleep related eating disorder (SRED) ? are actually diagnosable conditions for some people. NES is technically classified as disordered eating [2], but researchers believe it?s also related to sleep disorders, making it a sort of hybrid condition....
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Many cellular responses rely on the control of nucleocytoplasmic transport of transcriptional regulators. The Drosophila nucleoporin Nup88 is selectively required for nuclear accumulation of Rel proteins and full activation of the innate immune response. Here, we investigate the mechanisms underlying its role in nucleocytoplasmic transport. Nuclear import of an nuclear localization signal-enhan...
متن کاملHigh Dimensions and Heavy Tails for NES
The family of natural evolution strategies (NES) offers a principled approach to real-valued evolutionary optimization by following the natural gradient of the expected fitness on the parameters of its search distribution. While general in its formulation, existing research has focused only on multivariate Gaussian search distributions. We address this shortcoming by exhibiting problem classes ...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21176341