Useful Oral Administration of Glucagon-Like Peptide 1 Receptor Agonist (GLP-1RA) as Semaglutide (Rybelsus) for Type 2 Diabetes Mellitus (T2DM)

As recommended pharmacological agents for type 2 diabetes mellitus (T2DM), Glucagon-Like Peptide 1 receptor agonist (GLP-1Ra) is highly evaluated its various beneficial effects. Among them, semaglutide (Rybelsus) has been in focus useful oral formation with hypoglycemic agent (OHA). Administration per os possible due to the developed technique of absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate. Clinical efficacy was shown by a series Innovation Early Diabetes Treatment (PIONEER) enough weight reduction and decreased HbA1c. From results several PIONEER programs, 14 mg/day had reduced HbA1c values approximately 1.0-1.4%.