Use of Oral Vasopressin V2 Receptor Antagonist for Hyponatremia in Acute Brain Injury

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Use of oral vasopressin V2 receptor antagonist for hyponatremia in acute brain injury.

a Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul , Republic of Korea; b Departments of Neurosurgery and Neurology, The University of Texas Medical School at Houston, Houston, Tex. , c Department of Neurology, University of Maryland School of Medicine, Baltimore, Md. , and Departments of d Neurology and e Pharmacy, Columbia University College of Phys...

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Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist

Chronic hyponatremia is very rare in children and is often seen in the setting of congestive heart failure or liver failure in adults. Here, we report an 8-year-old child with hypothalamic glioma who presented with severe hyponatremia. Initial management consisted of fluid restriction. This was very difficult for the child to follow and the child developed bizarre drinking habits requiring inte...

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Acute effects of vasopressin V2-receptor antagonist on kidney AQP2 expression and subcellular distribution.

The acute effect of treatment with the vasopressin V2-receptor antagonist OPC-31260 (OPC) on aquaporin-2 (AQP2) distribution and expression in rat kidney was examined. Immunofluorescence and semi-quantitative immunoelectron microscopy revealed that 15 and 30 min of OPC treatment resulted in significant reduction in apical plasma membrane labeling of AQP2, with a concomitant increase in labeling...

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V2 Receptor Antagonist; Tolvaptan

Hyponatremia is the most common electrolyte disorder in hospitalized patients. Many studies documented that it was related to increased morbidity and mortality in patients with congestive heart failure, liver cirrhosis, and neurologic diseases. Although knowledge of hyponatremia has been cumulated, the optimal management of hyponatremia remains incompletely established in clinical practice beca...

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ژورنال

عنوان ژورنال: European Neurology

سال: 2013

ISSN: 1421-9913,0014-3022

DOI: 10.1159/000350844