Use and Safety of Unfractionated Heparin for Anticoagulation During Maintenance Hemodialysis
نویسندگان
چکیده
منابع مشابه
comparison of enoxaparin sodium and standard heparin for hemodialysis anticoagulation
methods this randomized, crossover study with parallel design was conducted in 45 patients who required maintenance hemodialysis due to end-stage renal failure. four patients with known bleeding disorders, receiving anticoagulant drugs and receiving drugs which could affect heparin activity were excluded. all patients were randomly assigned to receive either enoxaparin sodium (0.7 mg/kg) or sta...
متن کاملAssessment of the Adminstration of Low Molecular Weight Heparin for Hemodialysis Anticoagulation in Comparison to Standard Unfractionated Heparin
Background and Aim of Study: The use of Low-molecular-weight heparin (LMWH) for hemodialysis anticoagulation has been proposed as effective and safe for hemodialysis (HD) anticoagulation as standard unfractionated heparin (UFH). The aim of our study was to assess the use of LMWH for hemodialysis anticoagulation in comparison to UFH, including hemorrhagic events and clotting of the extracorporea...
متن کاملComparison of low-molecular-weight heparin (enoxaparin sodium) and standard unfractionated heparin for haemodialysis anticoagulation.
BACKGROUND Low-molecular-weight heparin (LMWH) has been suggested as providing safe, efficient, convenient and possibly more cost-effective anticoagulation for haemodialysis (HD) than unfractionated heparin, with fewer side-effects and possible benefits on uraemic dyslipidaemia. METHODS In this prospective, randomized, cross-over study we compared the safety, clinical efficacy and cost effect...
متن کاملThe use and limitations of unfractionated heparin.
Despite the development of newer anticoagulants, unfractionated heparin remains an indispensible agent in the treatment of thrombotic disorders. Heparin exerts its major effect via antithrombin, converting antithrombin to a more efficient inhibitor of circulating thrombin (factor IIa), factor Xa, factor IXa, factor XIIa, and kallikrein. However, due to the multiple anticoagulant mechanisms of h...
متن کاملSafety of low-molecular-weight heparin compared to unfractionated heparin in hemodialysis: a systematic review and meta-analysis
BACKGROUND Low molecular weight heparins (LMWH) have been extensively studied and became the treatment of choice for several indications including pulmonary embolism. While their efficacy in hemodialysis is considered similar to unfractionated heparin (UFH), their safety remains controversial mainly due to a risk of bioaccumulation in patients with renal impairment. The aim of this systematic r...
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ژورنال
عنوان ژورنال: American Journal of Kidney Diseases
سال: 2012
ISSN: 0272-6386
DOI: 10.1053/j.ajkd.2012.03.017