Ursodeoxycholic Acid in Intrahepatic Cholestasis of Pregnancy: A Systematic Review and Individual Participant Data Meta-analysis
نویسندگان
چکیده
(Abstracted from Lancet Gastroenterol Hepatol 2021;6:547–558) Ursodeoxycholic acid (UA) is a common treatment for intrahepatic cholestasis of pregnancy (ICP), and its use supported by the Society Maternal-Fetal Medicine. However, evidence benefit UA to fetal neonatal outcomes in this patient population unclear.
منابع مشابه
ursodeoxycholic acid and s-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy: a meta-analysis
conclusions udca decreased the pruritus score, tba, and alt levels more effectively than same, reducing the rate of preterm delivery for icp. evidence acquisition a meta-analysis of all randomized controlled trials (rcts) comparing udca, same, and combination therapy was performed. we carried out a literature search using pubmed, embase, the cochrane register of controlled trials, and the scien...
متن کاملUrsodeoxycholic Acid and S-adenosylmethionine for the Treatment of Intrahepatic Cholestasis of Pregnancy: A Meta-analysis
CONTEXT An optimal therapeutic strategy has not yet been identified for the pharmacological treatment of intrahepatic cholestasis of pregnancy (ICP). The aim of this study was to evaluate the efficacy and safety of ursodeoxycholic acid (UDCA) and S-adenosylmethionine (SAMe) in the treatment of ICP, both individually and in combination. EVIDENCE ACQUISITION A meta-analysis of all randomized co...
متن کاملIntrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid.
Intrahepatic cholestasis of pregnancy (ICP) is a disease characterized by generalized pruritus and biochemical cholestasis that appears typically during the last trimester of gestation. The most predictive and accurate markers for diagnosis and follow-up of ICP are increased total bile acid levels (above 11,0 micromol/L), enhanced cholic acid percentage (above 42%) and decreased glycine/taurine...
متن کاملEfficacy and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy.
UNLABELLED Background and aims. Patients with intrahepatic cholestasis of pregnancy (ICP) benefit from ursodeoxycholic acid (UDCA) treatment. Since there is still certain reluctance to use UDCA in pregnant women, mainly due to warnings in the official SPC information in respective drug leaflets, our objective was to assess the efficacy and safety of UDCA during pregnancy. MATERIAL AND METHOD...
متن کاملIntrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid.
Intrahepatic cholestasis of pregnancy (ICP) is characterized by troublesome maternal pruritus, elevated serum bile acids (> or =10 micromol/L) and increased fetal risk. Recently we determined a cutoff level of serum bile acids, > or =40 micromol/L, to be associated with impaired fetal outcome. We have now studied the effects of ursodeoxycholic acid (UDCA) and dexamethasone on pruritus, biochemi...
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ژورنال
عنوان ژورنال: Obstetrical & Gynecological Survey
سال: 2021
ISSN: ['1533-9866', '0029-7828']
DOI: https://doi.org/10.1097/01.ogx.0000792616.29408.2a